Rates of serious adverse events, including serious infections, malignancies and cardiovascular events were low and consistent with the expected background rates. The most common adverse events in Phase 3 clinical trials were arthralgia, headache, flushing, nasopharyngitis and upper respiratory tract infection.. This positive opinion is based on data from two large Phase 3 , multi-center, randomized, double blind, placebo-controlled studies involving almost 2,000 patients, in which the basis of the efficacy and safety of ustekinumab in the treatment of moderate to severe plaque psoriasis was scored evaluated.1 2 More than two thirds of the patients met the primary endpoint of each pivotal trial, at least 75 percent reduction in the psoriasis psoriasis and Severity Index at week after after only two doses at weeks 0 and Significant maintenance of PASI 75 response by at least 1 year in patients receiving maintenance therapy every 12 weeks was also demonstrated with a randomized withdrawal design in the first trial .
GPs are the first port of call at 93 percent of cases, which the identification and treatment of alternative causes of cognitive impairment listed is an important skill Clinical features of alternative causes of cognitive impairment. The CHMP approval of ustekinumab is for adults who did not respond, a contraindication have to have, or are intolerant to other systemic therapies including ciclosporin, methotrexate and PUVA a combination.1 That Nursing and Obstetrics Council has the UK regulator of two professions, cultivation and midwifery. In Training and the of the NMC is to protect of the public. It does this through maintaining a register of any nurses, midwife and eligible for expert public to train public health nurses in the UK and by the setting of standards for the education, training and behavioral. Is currently the number of registrants be through the six hundred and eighty sixth Which Nursing and Midwifery Programme Order 2001 , sets out the NMC role and responsibility..