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The multicenter, open-label scientific trial will be carried out in two parts and is planned to begin in nov 2014. Phase 1b is designed to determine the protection and tolerability of talimogene laherparepvec in combination with MK-3475 in patients with previously untreated, unresected, stage IIIB to IVM1a melanoma. The Phase 2 portion will evaluate efficacy, as assessed by the verified objective response rate , with talimogene laherparepvec in conjunction with MK-3475 versus MK-3475 alone in sufferers with previously untreated, unresected, stage IIIB to IVM1c melanoma.